潜在的COVID-19疗法来自重新设计的药物和草本小RNAs
Yang Yang1, Fengming Huang2, Xiangyu Qiao2
1Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
这项研究确定了16种潜在的食品和药物管理局 (FDA) 批准的药物用于治疗2019年新冠肺炎 (COVID-19) 疾病,并突出了12种具有有效草药小RNA (sRNA) 的中国传统药物 (TCM) 用于COVID-19治疗.
科学领域:
- 药理学 药理学是指药理学的学科.
- 病毒学 病毒学
- 基因组学就是基因组学.
背景情况:
- 对于严重急性呼吸系统综合征-冠状病毒-2 (SARS-CoV-2) 存在有限的治疗选择.
- 重新设计的食品和药物管理局 (FDA) 批准的药物和传统中国医学 (TCM) 组件,如草本小RNA (sRNAs),对2019年冠状病毒病 (COVID-19) 治疗有希望.
研究的目的:
- 确定FDA批准的药物和TCM草本sRNA作为潜在的COVID-19疗法.
- 为了分析患者的血液样本和选TCMs针对COVID-19的治疗疗效.
主要方法:
- 分析了63名COVID-19患者的血液样本,其中包括19例严重病例.
- 文献挖掘以证实药物疗效和选245个TCMs从本卡奥sRNA图谱.
- 在多分子I:C刺激的A549肺癌细胞中验证顶部TCM衍生sRNA.
主要成果:
- 确定了39种FDA批准的COVID-19治疗药物,其中23种已通过文献挖掘证实.
- 16种FDA批准的药物和12种TCM药物在患者队列中显示出对COVID-19治疗的持续潜力.
- 顶级TCMsRNA在细胞模型中证明了经过验证的效率.
结论:
- 建议16种FDA批准的重用药物作为潜在的COVID-19治疗方法.
- 突出了12种含有有效草本小RNA的中国传统药物,用于COVID-19治疗.
- 建议采用双重方法,将重定向药物和TCM衍生的sRNA用于COVID-19治疗.
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