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鱼类抗蛋白来源于雕塑中,通过在重复的家政基因中进行框架转移

Laurie A Graham¹, Peter L Davies¹

¹Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.

The FEBS journal

|June 26, 2024

概括

鱼类中的防蛋白 (AFP) 在多次融合进化. 这些蛋白质对于冰冷水域的生存至关重要,在雕刻者和鱼中显示出明显的进化路径.

科学领域:

进化生物学是进化的生物学.
分子生物学分子生物学
生物化学生物化学

背景情况:

抗蛋白 (AFP) 对海洋冷水鱼类至关重要,通过结合冰晶来防止结.
多种类型和分散分布的AFPs表明了复杂的进化历史,可能是由晚代热带冰河时期驱动的.

研究的目的:

为了研究鱼类I型抗蛋白的进化起源.
为了确定在雕塑中富含氨酸的阿尔法螺旋型I AFPs的祖先,并了解涉及的进化机制.

主要方法:

用比较基因组学和分子进化分析来追踪AFP基因的起源.
分析了基因重复,表子混合,移和点突变,以了解序列转换.
遗传学分析被用来确定AFPs的进化关系和独立起源.

主要成果:

标型I AFPs的祖先被确定为月球公园,这是一个内 плазма网膜膜蛋白质.
雕刻家AFP基因通过重复,外因子损失和将一个富含谷氨酸/谷氨酸的细分部分转化为富含氨酸的序列而进化.
类型I AFPs的起源不同,涉及从抗病毒蛋白基因的片段的放大.
雕刻者和鱼中I型AFPs的独立进化表明,结冰的α-螺旋结构具有强烈的融合选择.

结论:

第一种类型的AFP在不同的鱼系中通过不同的进化途径独立出现.
获得这些AFP使雕塑家能够在寒冷,冰冷的海洋环境中殖民,从而获得竞争优势.

关键词:

融合进化的趋同.基因放大基因放大基因放大结冰蛋白是一种结冰蛋白质.蛋白质的进化蛋白质的进化在海平面上形成的冰川.远距离的鱼类是远距离的

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