红细胞分布宽度/血清白蛋白比率与糖尿病病之间的关联
Jiaqi Chen1, Daguan Zhang2, Depu Zhou3
1Department of Endocrinology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Journal of diabetes
|June 26, 2024
概括
红细胞分布宽度 (RDW) /血清白蛋白比 (RA) 独立预测糖尿病糖尿病患者的糖尿病病 (DKD). 这种可访问的生物标志物可能有助于DKD风险分层.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 炎症标志物 炎症标志物
背景情况:
- 红细胞分布宽度 (RDW) /血清白蛋白比率 (RA) 被认为是一种新的炎症标志物.
- 以前的研究表明,RA与各种疾病的临床结果有关.
- 在评估糖尿病病 (DKD) 中,RA 的具体作用仍未得到充分研究.
研究的目的:
- 调查RDW/血清白蛋白比率 (RA) 和糖尿病病 (DKD) 之间的关联.
- 评估RA作为糖尿病患者DKD的潜在预测因素.
- 在分析中控制潜在的混因素.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 和温州医学大学 (WMU) 数据库 (2009-2018) 的回顾性队列分析.
- 包括4513名糖尿病患者,其中974人在NHANES诊断出DKD,462人在WMU.
- 多变量逻辑回归和倾向分数匹配 (PSM) 分析,以评估RA和DKD之间的独立关联.
主要成果:
- 较高的RA水平与NHANES队列 (OR=1.461,p < 0.00001) 糖尿病患者的DKD风险增加显著相关.
- 在调整了混因子和PSM分析后,RA仍然是DKD的独立预测因子 (调整=0.00994,PSM=0.02889).
- 在WMU队列中观察到一致的结果,加强了RA和DKD之间的关联 (p < 0.00001).
结论:
- RDW/血清白蛋白比率 (RA) 作为糖尿病病患者糖尿病病 (DKD) 的独立预测指标.
- RA是一种具有成本效益和易于获取的生物标志物.
- 在糖尿病病的风险分层中,RA显示出潜在的实用性.
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