Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

1.7K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.7K
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

463
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
463
Adrenergic Agonists: Indirect-Acting Agents01:25

Adrenergic Agonists: Indirect-Acting Agents

1.6K
Indirect-acting adrenergic agonists potentiate the effects of endogenous catecholamines through different mechanisms without directly binding to adrenoceptors.
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
1.6K
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

142
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
142
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

566
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
566
Altered States of Awareness01:06

Altered States of Awareness

174
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
174

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Psilocybin therapy for adult females with anorexia nervosa: pilot study.

The British journal of psychiatry : the journal of mental science·2026
Same author

Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.

Human brain mapping·2026
Same author

Clinical improvement following an integrative iboga microdosing protocol in post-concussive and hypoxic brain injury syndromes: a case series.

Frontiers in pharmacology·2026
Same author

The entropic brain today.

Brain : a journal of neurology·2026
Same author

Whole-blood transcriptomic response to whole-body hyperthermia in participants with major depressive disorder.

Brain, behavior, & immunity - health·2026
Same author

An international mega-analysis of psychedelic drug effects on brain circuit function.

Nature medicine·2026

相关实验视频

Updated: Jun 23, 2025

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

17.0K

心理模拟补偿与敏感化对比

Ari Brouwer1, Robin L Carhart-Harris2, Charles L Raison3,4,5,6

  • 1Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Pharmacology research & perspectives
|June 26, 2024
PubMed
概括

矛盾的是,仿生药物可以缓解精神病风险症状,如注意力缺陷和抑郁症. 新的模型,心理模拟补偿和敏感化,解释了这些药物对神经递质系统的影响.

关键词:
迷幻类精神药物 迷幻类精神药物精神错乱是一种精神病.这是一种Pychotomimetic模拟.精神分裂症是一种精神分裂症.敏感化 敏感化压力就是压力,压力就是压力.使用物质使用物质.

更多相关视频

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

11.6K
Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
09:39

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

12.7K

相关实验视频

Last Updated: Jun 23, 2025

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

17.0K
Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

11.6K
Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
09:39

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

12.7K

科学领域:

  • 神经科学是一个神经科学.
  • 心理药理学 心理药理学
  • 精神病学是一个精神病学.

背景情况:

  • 矛盾的是,仿生药物可以缓解与精神病相关的症状.
  • 像注意力缺陷,疼痛和抑郁症这样的症状与精神病风险有关.

研究的目的:

  • 介绍新的概念:心理模拟补偿和心理模拟敏感化.
  • 解释心理模拟药物缓解精神病风险症状的悖论.

主要方法:

  • 通过神经递质系统 (内大麻素,血清激素,谷氨酸激素,多巴胺激素) 理论化短期药物/压力效应 (补偿).
  • 描述长期影响 (敏感化),包括精神病类经历的逐渐加剧.

主要成果:

  • 心理模拟补偿:通过神经递质的参与,短期缓解缺陷.
  • 心理模拟感应:长期加剧的精神病经历与重复暴露.
  • 该模型将药物效应与压力和精神病风险相结合.

结论:

  • 拟议的模型为理解心理模拟药物作用提供了一个框架.
  • 突出了对精神病研究和治疗的理论和实际影响.