作为COVID-19结果的指标的Cq值:研究实验室参数之间的相关性
Hadi Safdari1, Saeede Bagheri1, Nasrin Talkhi2
1Department of Laboratory Sciences, School of Paramedical Sciences, Faculty of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Immunity, inflammation and disease
|June 26, 2024
概括
循环量化 (Cq) 水平与COVID-19患者的关键实验室标志物相关. 这些发现表明,Cq值与常规实验室检测相结合,可以帮助了解COVID-19疾病进展.
科学领域:
- 传染性疾病 传染性疾病
- 临床化学 临床化学
- 血液学 血液学 血液学
背景情况:
- 随着COVID-19的蔓延,全球健康面临着重大挑战.
- 了解疾病标志物对于患者管理至关重要.
研究的目的:
- 研究COVID-19患者的周期量化 (Cq) 值和各种实验室参数之间的关系.
- 评估Cq水平作为疾病严重程度指标的潜力.
主要方法:
- 一项涉及234名参与者的研究,分为COVID-19病例和对照.
- 实时PCR用于COVID-19的诊断.
- 分析完整血清,C反应蛋白 (CRP),红细胞沉积率 (ESR),乳酸脱酶 (LDH),D-二聚体,IgG和IgM水平.
主要成果:
- 在COVID-19患者中,中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),D-二次体,ESR,CRP和LDH的增加.
- 在COVID-19病例中观察到较低的淋巴细胞和血小板数量.
- 在Cq水平和淋巴细胞计数 (阳性) 和NLR (反向) 之间发现了显著的相关性.
结论:
- Cq水平与炎症标志物 (CRP,ESR),凝血标志物 (D-二次体) 以及COVID-19中的NLR和PLR等比率有显著的关联.
- 将Cq值与实验室参数相结合,可能为COVID-19提供一种有价值的预后工具.
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