怀孕期间的体力活动和循环炎症标志物和细胞因子:基于人口的队列研究
Poshmaal Dhar1, Luba Sominsky1,2, Martin O'Hely1
1Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.
Acta obstetricia et gynecologica Scandinavica
|June 26, 2024
概括
在怀孕期间进行适度体力活动 (PA) 与较低的系统性炎症有关. 低水平和高水平的PA都与炎症标志物增加有关,这表明U形关系.
科学领域:
- 免疫学 免疫学 免疫学
- 生殖健康 生殖健康
- 运动科学 运动科学
背景情况:
- 怀孕期间的体力活动 (PA) 提供了好处,可能是通过免疫系统调节.
- 现有的证据是不一致的,主要来自高风险人群.
- 这项研究调查了PA对一般孕妇群体炎症标志物的影响.
研究的目的:
- 估计怀孕期间身体活动对全身炎症标志物和细胞因子的影响.
- 为了确定遵守推的PA水平是否会影响炎症概况.
- 探索不同水平的PA和孕妇免疫标记之间的关系.
主要方法:
- 使用了巴沃恩婴儿研究,这是一组1064名母亲的产前队列.
- 参与者在妊娠28周使用国际PA问卷报告了PA.
- 使用回归模型测量和分析了系统性炎症标志物 (hsCRP,GlycA) 和17种细胞因子.
主要成果:
- 与中度PA组相比,低和高PA组的hsCRP水平显著更高.
- 在高PA类别的女性中,呈现出高水平的IL-4 (IL-4) 和IL-9.
- 增加的活力活动 (MET分钟/周) 与较低的糖蛋白乙 (GlycA) 水平有关.
结论:
- 在怀孕期间中度的PA与减少的全身炎症有关.
- 无论是不够的还是过度的PA水平都可能增加炎症.
- 在怀孕期间,PA似乎调节了免疫反应,因此需要进一步研究临床结果.
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