营养不良和后急性COVID-19后果之间的关联:一个回顾性队列研究
Jana Ponce1,2, A Jerrod Anzalone3, Makayla Schissel4
1College of Allied Health Professions, University of Nebraska Medical Center, Omaha, Nebraska, USA.
JPEN. Journal of parenteral and enteral nutrition
|June 26, 2024
概括
营养不良显著增加了从严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 恢复的个人死亡和再感染的风险. 早期营养查可以帮助预防COVID-19后的负面长期健康结果.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 营养科学 营养科学
背景情况:
- 长期冠状病毒病 (COVID-19) 在SARS-CoV-2感染后呈现持续的健康问题,影响生活质量.
- 营养不良是严重急性疾病的已知危险因素,但其在COVID-19后的结果中的作用不明.
- 这项研究调查了营养不良对SARS-CoV-2感染的长期后果的影响.
研究的目的:
- 为了评估营养不良和SARS-CoV-2感染后不良后急性结果之间的关联.
- 识别与营养不良相关的特定风险,包括死亡,长期COVID诊断和再感染.
- 检查住院患有住院营养不良的住院患者的结果.
主要方法:
- 利用国家COVID队列协作数据库识别至少28天后的SARS-CoV-2感染患者队列.
- 采用多变量Cox比例危险模型来评估营养不良对COVID-19后遗症的影响.
- 对在医院获得的营养不良患者进行了子组分析.
主要成果:
- 这项研究包括超过430万个人,其中1.8%的人有营养不良史.
- 营养不良与急性后阶段的死亡风险 (aHR: 2.10) 和SARS-CoV-2再感染风险 (aHR: 1.52) 显著增加.
- 医院获得的营养不良与死亡风险增加和长期COVID诊断相关.
结论:
- 在急性SARS-CoV-2感染期间进行营养查对于早期识别营养不良至关重要.
- 对营养不良的及时干预可以减轻严重和改变生活的急性COVID-19后结果.
- 建议将营养评估纳入COVID-19护理途径.
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