映射运动皮质网络刺激性和连接性变化 在De Novo帕金森病中的变化
Giorgio Leodori1,2, Maria Ilenia De Bartolo2, Claudia Piervincenzi1
1Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
概括
运动皮层的低兴奋性是帕金森病 (PD) 的早期标志物. 在早期的PD中没有明显的补充前运动区域过激,这表明它在疾病进展的晚期发展.
科学领域:
- 神经科学是一个神经科学.
- 运动障碍 运动障碍
- 神经学 神经学
背景情况:
- 以前的研究表明,在晚期帕金森病 (PD) 中,运动皮层刺激性发生变化.
- 具体变化包括初级运动皮层 (M1) 刺激能力的降低和前补充运动区域 (SMA) 刺激能力的增加.
研究的目的:
- 为了确定M1和SMA前兴奋性异常是否存在于早期的,未使用药物的PD.
- 探索行为相关性和早期PD中皮层-皮下连接的关系.
主要方法:
- 28名早期的新发性病患者和28名健康对照 (HCs) 接受了跨磁刺激-脑电图 (TMS-EEG).
- 从M1和SMA前记录了TMS唤起的潜力 (TEP).
- 进行了有关白质通道的动态指触和扩散张力成像 (DTI).
主要成果:
- 与HC相比,De novo PD患者显示M1 TEP P30幅度降低.
- 在SMA前的TEP N40振幅在各组之间是相似的.
- PD患者表现出受损的手指敲击动力学和改变的白质完整性,但这些与TEP发现无关.
结论:
- M1低兴奋性是帕金森病的早期特征.
- 在PD的早期阶段,SMA前的过度兴奋性并不明显.
- M1低兴奋性可以作为帕金森症状态的潜在生物标志物.
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