新生儿呼吸道并发症在怀孕36-38周的双胞胎
Haruna Kawaguchi1, Yoshihiro Kuritani2, Ryo Yamamoto1
1Department of Maternal-Fetal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan.
对于没有并发症的双胞胎,在37周后分娩可以减少新生儿呼吸问题. 在36周的早产表明这些婴儿的风险更高.
科学领域:
- 围产儿医学 围产儿医学
- 新生儿科学 新生儿科学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 双胞胎怀孕会增加围产期死亡率和发病率的风险.
- 在没有并发症的双胞胎中,早产 (36-38周) 是常见的,以防止胎儿死亡.
- 然而,早产会增加新生儿呼吸道并发症的风险.
研究的目的:
- 在怀孕36周至38周之间分娩的双胞胎中评估围产呼吸道并发症.
- 分析妊娠年龄在分娩时对双胞胎呼吸系统结果的影响.
- 根据胆管性来比较呼吸道病率.
主要方法:
- 对1608名在妊娠36周至38周之间分娩的双胞胎进行了回顾性队列研究 (2008年1月至2020年6月).
- 主要结局包括复合新生儿呼吸道疾病 (RDS,TTN,MAS,通风,CPAP).
- 多变量逻辑回归分析了妊娠年龄,胆管性和呼吸系统发病率之间的关系.
主要成果:
- 新生儿呼吸系统综合发病率为 19.4% (36w),10.7% (37w) 和9.2% (38w) 的双胞胎.
- 单胆双胞胎的发育率分别为13.6% (36w),8.7% (37w) 和9.4% (38w).
- 36周出生的二双胞胎的发病率明显高于37周的双胞胎;单双胞胎没有显著差异.
结论:
- 在没有并发症的二二双胞胎怀孕中,建议在37周后分娩.
- 这种时间可能有助于最大限度地减少新生儿呼吸道并发症.
- 怀孕年龄和胆管性是优化双胞胎分娩时间的关键因素.
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