与代谢功能障碍相关的脂肪性肝病与1型糖尿病的范围中的时间更差有关
Chloë Aernouts1,2, Sarah P W Beldé1,2, Julie Lambrechts1,2
1Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Edegem, Belgium.
Diabetes, obesity & metabolism
|June 26, 2024
概括
持续的葡萄糖监测指标,如范围内的时间,范围以上的时间和范围以下的时间,与1型糖尿病中代谢功能障碍相关的脂肪性肝病 (MASLD) 有关. 这些血糖控制标记,以及腰围和血压,独立地预测MASLD.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 1型糖尿病 (T1D) 的管理涉及复杂的代谢控制.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是各种患者群体的一个新兴问题.
- 在T1D中,血糖控制和肝脏健康之间的相互作用需要进一步调查.
研究的目的:
- 检查持续血糖监测 (CGM) 衍生的血糖计与T1D成年人中MASLD的患病率之间的关联.
- 确定该队列中与MASLD独立相关的特定CGM参数和临床因素.
主要方法:
- 一项涉及302名T1D成人使用CGM设备的横截面研究.
- 诊断MASLD是基于腹部超声波和心脏代谢标准.
- 使用逆向多变量逻辑回归分析来确定MASLD的独立预测因子.
主要成果:
- 在17%的参与者中发现了MASLD;代谢综合征在MASLD患者中更为普遍 (65%对25%).
- 较低的范围内时间 (TIR),范围以下时间 (TBR) 和范围以上时间 (TAR) 与MASLD相关.
- 独立地与MASLD相关的是TIR,TAR,TBR,腰围和缩血压.
结论:
- 从CGM衍生的血糖计,特别是TIR,TAR和TBR,与T1D中的MASLD有显著的关联.
- 临床参数包括腰围和静脉血压也是MASLD的独立预测因素.
- 这些发现强调了全面的血糖控制和代谢监测对T1D患者有 MASLD 风险的重要性.
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