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Updated: Jun 23, 2025

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein
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GBA1的注释被其编码蛋白质的假基因GBAP1所隐藏

Emil K Gustavsson1,2, Siddharth Sethi1,3, Yujing Gao3

  • 1Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.

Science advances
|June 26, 2024
PubMed
概括

研究人员使用长时间读取的RNA测序来准确测量人类大脑中的GBA1及其伪基因GBAP1的基因表达. 这揭示了这些基因的新型非溶解体功能,影响了帕金森病和高氏病的研究.

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