电子尼古丁输送系统 (ENDS) 的电子液体和气溶中的有害和潜在有害成分
Samantha M Reilly1, Tianrong Cheng1, Charles Feng1
1Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, Maryland 20993-0002, United States.
这项研究量化了电子尼古丁输送系统 (ENDS) 中的有害和潜在有害成分 (HPHC). 许多HPHC可以在ENDS电子液体和气溶中量化,为监管和公共卫生评估提供了信息.
科学领域:
- 烟草监管科学 烟草监管科学
- 分析化学 分析化学
- 公共卫生 公共卫生
背景情况:
- 美国食品和药物管理局 (FDA) 在传统烟草产品中确定了93种有害和潜在有害成分 (HPHC).
- 美国食品和药物管理局2016年的认定规则扩大了对电子尼古丁递送系统 (ENDS) 的监管,但关于ENDS电子液体和气溶中的HPHCs的知识差距仍然存在.
研究的目的:
- 在以前缺乏信息的ENDS电子液体和气溶中识别和实验量化HPHC.
- 提供数据以告知ENDS的监管要求和公共卫生评估.
主要方法:
- 进行了全面的文献搜索,以确定在ENDS中有限的量化数据的HPHC.
- 在37个ENDS品牌的电子液体和气溶中使用ISO 17025认证的实验室实验量化了选定的HPHC.
- 根据可用的验证分析方法和量化极限 (LOQ) 来确定HPHC的量化能力.
主要成果:
- 文献搜索发现了66种电子液体和68种气溶HPHC,其量化信息有限.
- 总共有36个HPHC (39%) 在ENDS电子液体和34个HPHC (37%) 在气溶中可量化.
- 在电子液体和气溶中发现有25个HPHC是可量化的,这表明潜在的转移,出或形成.
结论:
- 在ENDS电子液体和气溶中检测到许多HPHC的可量化的水平.
- 这些发现为监管机构和制造商提供了关于HPHC报告和风险评估的关键数据.
- 结果支持公开的公共卫生沟通,了解与ENDS使用相关的潜在风险.
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