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通过"吃"外细胞聚合物物质来为伤口再生提供强大的抗生物膜模式的工程益生菌生物异质连接
Miao Qin1, Xiumei Zhang1, Haiyang Ding2
1Research Center for Nano-Biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Advanced materials (Deerfield Beach, Fla.)
|June 26, 2024
概括
一种新的益生菌生物异构连接 (P-bioHJ) 通过降解细胞外聚合物质 (EPS) 和产生活性氧物种 (ROS) 有效地消除生物膜. 这种P-bioHJ还通过减少炎症和增强抗氧化活性来促进伤口愈合.
科学领域:
- 生物材料科学 生物材料科学
- 传染性疾病 传染性疾病
- 纳米技术纳米技术
背景情况:
- 生物膜结构阻碍了抗微生物的透,导致持续的感染.
- 细胞外聚合物物质 (EPS) 在生物膜中形成保护性屏障.
- 开发有效的抗菌膜策略对于治疗感染至关重要.
研究的目的:
- 开发一种益生菌生物异质结 (P-bioHJ) 用于对抗生物膜感染.
- 研究P-bioHJ的抗菌膜,抗氧化剂和伤口愈合特性.
- 探索EPS降解的机制和由P-bioHJ产生的ROS.
主要方法:
- 使用 Lactobacillus rhamnosus 和 MXene (Ti3C2) 量子点/FeS 异质连接制造P-bioHJ.
- 在体外和体内对抗生素膜疗效的评估.
- 评估抗氧化和抗炎作用,包括ROS清除和NF-κB通路调节.
- 评估伤口愈合的加速.
主要成果:
- P-bioHJ成功降解了EPS,导致生物膜崩并增强了抗菌素的透.
- 对P-bioHJ的NIR照射产生了ROS和热能,以有效地消除生物膜.
- P-bioHJ表现出显著的抗氧化和抗炎作用,减少ROS和减轻NF-κB信号传递.
- 在P-bioHJ治疗后,体内观察到加速的伤口愈合.
结论:
- P-bioHJ提供了一种双重作用的方法,用于生物膜消除和伤口愈合.
- 该P-bioHJ系统有效地分解EPS,并利用ROS/热疗法.
- 这项研究为生物膜相关感染和伤口再生提供了一个有前途的治疗策略.
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