阴道癌的发病率分布,风险因素和趋势:基于全球人口的研究
Junjie Huang1,2, Sze Chai Chan1, Wing Sze Pang1
1The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, China.
概括
全球阴道癌发病率正在上升,中南亚和南非的发病率更高. 不安全的性行为和艾滋病毒感染是关键的危险因素,强调了针对性干预和HPV疫苗接种的必要性.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 阴道癌是一种罕见但严重的妇科恶性瘤.
- 了解其发病率,风险因素和趋势对于有效的公共卫生战略至关重要.
研究的目的:
- 调查阴道癌的全球发病率,风险因素和时间趋势.
- 为了确定受阴道癌症影响最大的地区和人口.
主要方法:
- 使用来自全球癌症登记册和卫生组织的数据进行了回顾性观察研究.
- 计算了年龄标准化率 (ASR) 并使用结点回归分析了趋势.
- 使用回归分析检查了风险因素 (例如,不安全的性行为,艾滋病毒,HPV) 和发病率之间的关联.
主要成果:
- 2020年,全球报告了17908例新的阴道癌症病例 (ASR=0.36).
- 在中南亚和非洲南部观察到的发病率最高.
- 不安全的性行为和艾滋病毒感染是显著的危险因素. 观察到全球发病率上升的趋势,冰岛,智利,巴林和英国的发病率明显增加.
结论:
- 显著的区域差异和已识别的风险因素需要有针对性的干预和教育,特别是在人类发展指数 (HDI) 较低的地区.
- 增加的发病率趋势强调迫切需要提高人类乳头瘤病毒 (HPV) 疫苗接种率,以预防阴道癌症.
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