雌激醇调节了情绪调节网络中有效连接的变化
Birgit Derntl1, Corinna H Eber2, Lydia Kogler1
1Department of Psychiatry and Psychotherapy, Women's Mental Health & Brain Function, Tübingen Center for Mental Health (TüCMH), University of Tübingen, Tübingen, Germany; German Center for Mental Health (DZPG), Partner site Tübingen, Germany.
Psychoneuroendocrinology
|June 26, 2024
概括
雌激醇 (E2) 影响大脑网络动态,以调节情绪. 较高的E2水平改变了神经连接,将头顶连接到前额叶区域,并预测了更好的情绪调节能力.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 心理学 心理学 心理学
背景情况:
- 卵巢激素,特别是雌激素 (E2),影响情绪处理,包括识别,记忆和调节.
- 以前的研究利用基于任务的fMRI来探索E2在情感体验中的神经支柱.
研究的目的:
- 调查静止时的内在网络动态,具体指导的有效连接是否受到E2级别的调制.
- 为了确定这些静止状态网络动态是否与行为情绪调节能力有关.
主要方法:
- 29名自然循环女性接受了两次休息状态fMRI扫描,接受了安慰剂或E2瓦莱拉特.
- 情绪调节能力是通过要求对负面图像下调情绪反应的任务来评估的.
- 光谱动态因果建模分析了预定义的神经网络中的有效连接,用于情绪调节和反应.
主要成果:
- 与安慰剂相比,雌激醇 (E2) 管理改变了情绪调节和反应网络的有效连接.
- 根据E2.2,在调节网络的前额区域观察到不同的连接模式.
- 在E2条件下,与前额叶皮层的连接预测了情绪调节能力.
结论:
- 雌激素水平显著影响参与情绪调节和反应的神经网络的有效连接.
- 激素调节E2可能在治疗情绪失调障碍方面起到支持作用.
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