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在婴儿男性割礼中比较阴茎微生物组:莫根与香格里拉
Juan E Salazar1, Daniel E Park1, Nahid Punjani2
1Antibiotic Resistance Action Center, Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, 20052, USA.
EBioMedicine
|June 26, 2024
概括
使用Mogen Clamp或ShangRing进行早期婴儿男性割礼 (EIMC) 会改变阴茎微生物组. 这两种方法都能减少厌氧生物和尿病原体,类似于成人割礼的结果.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 儿科 儿科 儿科
背景情况:
- 婴儿阴茎微生物组的组成及其通过早期婴儿男性割礼 (EIMC) 的改变并没有得到很好的描述.
- 使用各种方法进行EIMC,包括手术 (Mogen Clamp) 和非手术 (ShangRing) 设备.
研究的目的:
- 为了描述婴儿阴茎 (冠状) 微生物群.
- 评估两种EIMC方法 (Mogen Clamp和ShangRing) 对婴儿阴茎微生物群的影响.
主要方法:
- 在乌干达进行了一项随机试验,涉及30名接受EIMC的婴儿.
- 在基线和在割礼后的第7天和第14天收集了冠状腺样.
- 使用16S rRNA基因测序和qPCR分析阴茎微生物组合.
主要成果:
- 在EIMC之前,婴儿阴茎微生物组包括任择性和严格无气体的混合物.
- 通过Mogen Clamp和ShangRing的EIMC,导致无氧细菌 (例如Prevotella,Veillonella) 的减少.
- EIMC导致皮肤相关的有机无气体 (例如,Corynebacterium,Staphylococcus) 的增加.
结论:
- 莫根和香格里拉EIMC都显著改变了婴儿阴茎微生物组合.
- 这些变化涉及厌氧生物和尿病原体的减少,与成年男性割礼研究的发现一致.
- 两种EIMC方法都没有导致Clostridium tetani检测的增加.
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