当前的管理策略和结果在患上上皮上腺癌的儿童
Ioannis A Ziogas1, Jonathan L Hills-Dunlap1, Kristine S Corkum1
1Division of Pediatric Surgery, Department of Surgery, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, Colorado; Surgical Oncology Program, Children's Hospital Colorado, Aurora, Colorado.
The Journal of surgical research
|June 26, 2024
概括
在美国,小儿上腺皮质癌 (ACC) 的管理主要涉及手术和化疗. 诊断时的转移和非转移病例中较大的年龄与较差的生存结果有关.
科学领域:
- 儿科瘤学 儿科瘤学
- 内分泌手术 内分泌手术
- 癌症流行病学 癌症流行病学
背景情况:
- 皮上腺癌 (ACC) 是一种罕见的,侵袭性的儿科内分泌瘤.
- 最近的美国国家关于儿科ACC管理和结果的数据缺乏.
- 这项研究解决了关于儿科ACC的最新信息的需求.
研究的目的:
- 检查儿科ACC的临床特征.
- 分析目前儿科ACC的管理策略.
- 确定儿科ACC的结局和生存率.
主要方法:
- 国家癌症数据库 (2004-2019) 的回顾性分析.
- 包括被诊断患有ACC的儿科患者 (<18岁).
- 使用卡普兰-梅尔,日志等级测试和考克斯回归的统计分析.
主要成果:
- 分析了78例儿科ACC病例;中位数年龄为10岁,中位数瘤大小为10.2厘米.
- 35.9%的患者在诊断时发生了转移;84.6%接受了手术,56.4%接受化疗.
- 一,三,五年总生存率分别为87.0%,62.0%和60.1%.
结论:
- 美国儿科ACC治疗通常包括手术和化疗.
- 诊断时的转移独立地预测了较低的整体存活率.
- 在非转移性ACC中,年龄的增加独立地预测了较低的整体存活率.
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