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袖子胃切除术保护大鼠免受高血压,原因是肠道微生物组的变化
Matthew Barron1, Deemantha G Fernando1, Samantha N Atkinson2
1Department of Surgery, Milwaukee, Wisconsin.
The Journal of surgical research
|June 26, 2024
概括
从袖子胃切除术 (SG) 鼠的便物转移降低了未经手术的老鼠的血压,表明肠道微生物组直接影响高血压. 这表明SG后的微生物转移是改善血压的关键.
科学领域:
- 代谢手术 代谢手术
- 微生物组研究 微生物组研究
- 高血压研究 高血压研究
背景情况:
- 袖子胃切除术 (SG) 改善高血压,可能是通过肠道微生物群的转变,独立于减肥.
- 以前的研究表明,SG,体重减轻和肠道微生物群的改变之间存在联系.
- 这项研究调查了肠道微生物组在SG诱导的高血压改善中的直接作用.
研究的目的:
- 确定SG后肠道微生物组的改变是否可以直接改善血压.
- 评估从SG大鼠的便物质转移 (FMT) 对接受动物高血压的影响.
- 分析FMT后肠道微生物组组成和多样性的变化.
主要方法:
- 肥胖的雄性Zucker老鼠接受了SG或Sham手术.
- 便物质转移 (FMT) 使用后SG或后Sham大鼠的便进行.
- 接收者大鼠每天接受口服FMT10周,评估体重,食物摄入量,葡萄糖耐受性和血压.
主要成果:
- 与载体相比,SG-FMT显著降低了接受者大鼠的系统血压 (126.8 mmHg与151.8 mmHg相比).
- 与Sham-FMT和载体治疗相比,SG-FMT改变了肠道微生物的β多样性.
- 微生物序列变异显著预测了FMT组,突出了特定的微生物贡献.
结论:
- 在SG后的肠道微生物变化和血压调节之间存在直接联系.
- 在SG之后,特定的肠道微生物变化对于改善与肥胖相关的高血压至关重要.
- 需要进一步的研究来识别这些微生物,以便在代谢手术中临床转化.
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