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Updated: Jun 23, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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具有特征性的结合模式的SARS-CoV-2主要蛋白酶抑制剂的新型设计

Yan Zhu1, Jiaolong Meng2, Bo Feng3

  • 1Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen 518112, China.

Structure (London, England : 1993)
|June 26, 2024
PubMed
概括

使用基于结构的设计开发了针对SARS-CoV-2主要蛋白酶 (Mpro) 的新型抑制剂. 这些抑制剂通过独特的共价相互作用来破坏病毒复制,显示出治疗COVID-19的潜力.

关键词:
这就是SARS-CoV-2病毒.冠状病毒冠状病毒的新冠病毒.药物耐药性 耐药性 药物耐药性抑制剂抑制剂的使用主要蛋白质酶的主要蛋白质酶

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