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相关概念视频

Gene-Environment Interactions01:20

Gene-Environment Interactions

286
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
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Dimensions of Health and Illness01:21

Dimensions of Health and Illness

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The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
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Models of Health Promotion and Illness Prevention II01:18

Models of Health Promotion and Illness Prevention II

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The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results...
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Types of Toxins01:36

Types of Toxins

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
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Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

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Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
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相关实验视频

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在精确的环境健康框架内,基因与环境的相互作用.

Alison A Motsinger-Reif1, David M Reif2, Farida S Akhtari1

  • 1Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Durham, NC, USA.

Cell genomics
|June 26, 2024
PubMed
概括

基因与环境的相互作用 (GEIs) 对于理解疾病发展至关重要. 将暴露数据集成到精确环境健康 (PEH) 中可以改善疾病预测和预防策略.

关键词:
环境暴露环境暴露环境正义就是环境正义.流行病学流行病学表观遗传学是指表观遗传学.基因与环境的相互作用遗传学 遗传学 遗传学 是一个精确度环境健康环境健康

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科学领域:

  • 遗传学 是一个遗传学.
  • 环境健康 环境健康
  • 流行病学 流行病学

背景情况:

  • 了解基因与环境相互作用 (GEI) 对阐明疾病病因至关重要.
  • 在人类发展的各个阶段,GEI扮演着重要的角色.
  • 在准确测量环境因素方面存在挑战.

研究的目的:

  • 审查目前GEI研究的现状.
  • 讨论GEI研究设计的演变.
  • 突出将 GEI 发现转化为精密环境健康 (PEH) 的转化.

主要方法:

  • 对候选基因环境研究和全基因组相互作用研究 (GWIS) 的审查.
  • 在调解GEI效应时探索多学科方法.
  • 讨论GEI分析方法和大规模数据集的进展.

主要成果:

  • GEI分析在了解复杂的疾病机制方面具有优势.
  • 多omics数据可以揭示GEI中的调解效应.
  • 大规模的数据集对于强大的GEI发现至关重要.

结论:

  • 在疾病预测和预防方面,GEI具有重要意义.
  • 将 GEI 发现转化为 PEH 应用对于医疗保健和公共卫生至关重要.
  • 建议将曝光组整合到PEHomics研究中.