在精确的环境健康框架内,基因与环境的相互作用.
Alison A Motsinger-Reif1, David M Reif2, Farida S Akhtari1
1Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Durham, NC, USA.
基因与环境的相互作用 (GEIs) 对于理解疾病发展至关重要. 将暴露数据集成到精确环境健康 (PEH) 中可以改善疾病预测和预防策略.
科学领域:
- 遗传学 是一个遗传学.
- 环境健康 环境健康
- 流行病学 流行病学
背景情况:
- 了解基因与环境相互作用 (GEI) 对阐明疾病病因至关重要.
- 在人类发展的各个阶段,GEI扮演着重要的角色.
- 在准确测量环境因素方面存在挑战.
研究的目的:
- 审查目前GEI研究的现状.
- 讨论GEI研究设计的演变.
- 突出将 GEI 发现转化为精密环境健康 (PEH) 的转化.
主要方法:
- 对候选基因环境研究和全基因组相互作用研究 (GWIS) 的审查.
- 在调解GEI效应时探索多学科方法.
- 讨论GEI分析方法和大规模数据集的进展.
主要成果:
- GEI分析在了解复杂的疾病机制方面具有优势.
- 多omics数据可以揭示GEI中的调解效应.
- 大规模的数据集对于强大的GEI发现至关重要.
结论:
- 在疾病预测和预防方面,GEI具有重要意义.
- 将 GEI 发现转化为 PEH 应用对于医疗保健和公共卫生至关重要.
- 建议将曝光组整合到PEHomics研究中.
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