肠道微生物组是否会影响磁盘健康和疾病? 失生症,病原生物和磁盘炎症之间的相互作用:一个试点研究
Shanmuganathan Rajasekaran1, Gowdaman Vasudevan2, Chitraa Tangavel2
1Department of Spine Surgery, Ganga Hospital, 313, Mettupalayam Rd, Coimbatore, India.
概括
由改变的肠道微生物群特征的肠道失生症与磁盘退化和炎症有关. 这项研究强调了肠道健康和脊椎盘健康之间的联系,并提出了新的预防策略.
科学领域:
- 微生物组研究的研究.
- 炎症和疾病 炎症和疾病
- 脊柱的健康 脊柱的健康
背景情况:
- 肠道微生物组的改变与全身性炎症有关.
- 肠道健康对脊椎盘完整性的影响仍未得到充分研究.
研究的目的:
- 在有或没有磁盘退行症的个体中描述肠道微生物群.
- 阐明肠道失生症在人类磁盘健康中的作用.
主要方法:
- 实验性病例对照研究,比较40名患有椎间盘退行症 (DG) 的患者和20名健康志愿者 (HV).
- 16S V3-V4 rDNA 便样本的肠道转基因组分析.
- 血清C反应蛋白 (CRP) 和脂肪酸结合蛋白5 (FABP5) 的测量.
主要成果:
- 与HV相比,在DG患者中观察到显著的肠道失调,以及在Modic和非Modic亚组之间.
- 在Modic群中,有益细菌 (Bifidobacterium,Ruminococcus) 的消耗和病原生物 (Streptococcus,Prevotella) 的丰富.
- 在GD患者中,Firmicutes/Bacteroidetes比率降低,短链脂肪酸 (SCFA) 生产细菌减少,CRP和FABP5升高.
结论:
- 肠道失生症,改变的微生物比率,减少SCFA的产生,以及增加的炎症都与磁盘退化有关,特别是Modic变化.
- 研究结果提供了关于磁盘退化的机制和预防的潜在途径的见解.
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