维生素D和基因多态性对甲状腺过氧化酶抗体阳性敏感性的影响
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Updated: Jun 22, 2025

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
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Jing Cheng1, Lin Ye1, Yingchao Chen1
1Shanghai 9th Peoples Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Department of Endocrinology, No. 639, Zhizaoju Road, Shanghai, CN, PR China.
The American journal of the medical sciences
|June 26, 2024
概括
维生素D缺乏和特定的基因变异增加了甲状腺过氧化酶抗体 (TPOAb) 阳性在哈希莫托的甲状腺炎的风险. 遗传风险得分突出了这一关联,特别是在维生素D水平低的个体中.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 哈西莫托甲状腺炎 (HT) 的病因涉及复杂的遗传和环境因素.
- 维生素D在HT病变发生过程中的确切作用尚不清楚.
- 研究维生素D和基因多态化对甲状腺过氧化酶抗体 (TPOAb) 阳性影响至关重要.
研究的目的:
- 为了检查维生素D水平,特定基因多态 (rs11675434,rs9277555,rs301799) 和TPOAb阳性之间的关联.
- 为了计算TPOAb阳性的一种加权遗传风险得分 (TPOAb-GRS).
- 探索维生素D状态和对TPOAb阳性遗传倾向之间的相互作用.
主要方法:
- 分析了来自中国东部 (2014-2016) 的9966名参与者的数据.
- 测量25~OH) D,甲状腺激素和自身免疫抗体.
- 三个SNP的基因定型和TPOAb-GRS的计算.
主要成果:
- 阳性TPOAb个体中女性比例较高,维生素D水平较低.
- 特定的基因型 (rs9277555 GG,rs11675434 TT) 和TPOAb-GRS与TPOAb阳性显著相关.
- TPOAb-GRS与TPOAb阳性之间的关联仅在维生素D缺乏组中显著.
结论:
- 由rs9277555和rs11675434驱动的TPOAb-GRS与汉族中国人口的TPOAb阳性有关.
- 维生素D状态调节了对TPOAb阳性的遗传影响.
- 这些发现突显了HT中维生素D和遗传学之间的相互作用.
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