系统性炎症反应指数与美国风湿性关节炎成年人全因和心血管死亡率的增加有关

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Wei Wang¹, Wei Yao¹, Wanyun Tang¹

¹Department of Orthopedics, Dandong Central Hospital, China Medical University, Dandong, China.

Preventive medicine

|June 26, 2024

概括

系统性炎症反应指数 (SIRI) 显示了类风湿性关节炎 (RA) 患者与死亡风险的非线性正相关性. 较高的SIRI水平与RA中所有原因和心血管死亡率的增加有关.

科学领域:

类风湿病学类风湿病学
心血管医学心血管医学
炎症生物标志物炎症生物标志物

背景情况:

类风湿性关节炎 (RA) 是一种慢性系统性炎症性自身免疫性疾病.
在RA患者中,全身炎症反应指数 (SIRI) 的预后意义尚不清楚.
了解像SIRI这样的炎症标志物对于RA患者的治疗结果至关重要.

研究的目的:

调查SIRI与RA患者因任何原因死亡率之间的关联.
为了检查SIRI和RA患者心血管死亡率之间的关系.
探索SIRI在RA相关死亡率中的调解作用.

主要方法:

从NHANES (1999-2020) 对2656名RA患者的回顾性分析.
卡普兰-梅尔曲线,多变量考克斯回归和限制立方线用于评估死亡风险.
进行了子组和调解分析,以探索特定的关联.

主要成果:

在SIRI和所有原因和心血管死亡率之间发现了非线性正相关性.
一个SIRI水平为1.12表明过渡到更高的死亡风险.
在RA和死亡风险之间的关联中,SIRI调解了12.6%,女性和高BMI子组的效果更强.

结论:

系统性炎症反应指数 (SIRI) 是RA患者死亡率的显著非线性预测指标.
在类风湿性关节炎中,SIRI与全因和心血管死亡率有关.
根据SIRI的指示,炎症在RA预后和死亡风险中起着关键作用.

关键词:

死亡率死亡率死亡率尼汉斯 (NHANES) 是一个名人.类风湿性关节炎类风湿性关节炎类风湿性关节炎斯里里斯拉夫斯里里斯拉夫系统性炎症反应指数

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