可卡因与西洛梅塔佐林对比,以防止鼻腔输管后的表:一个随机试验
Mo H Larsen1,2, Oscar Rosenkrantz3, Andreas Creuzburg1,2
1Department of Anaesthesiology, Centre of Head and Orthopaedics Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Acta anaesthesiologica Scandinavica
|June 26, 2024
概括
克西罗米塔佐林和可卡因同样可以在鼻内输管过程中防止表. 两种药物都没有显示出减少出血的显著差异,这表明其他因素应该指导血管收缩剂的选择.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 鼻内输管带有表 (鼻血) 的风险.
- 可卡因和西洛梅塔佐林被用作鼻腔脱血剂来减轻这种风险.
- 这项研究比较了西洛梅塔佐林与可卡因在预防表症方面的疗效.
研究的目的:
- 为了确定西洛梅塔佐林是否比可卡因更有效地预防鼻腔输管输管后的表.
- 为了比较接收西洛梅他林和接收可卡因的患者之间出血的发生率.
主要方法:
- 进行了一项随机对照试验,患者接受了鼻内输管.
- 患者在输管之前接受了4%的可卡因或0.05%的西洛梅塔佐林.
- 输管后立即评估表性,并监测生命体征和不良事件.
主要成果:
- 在接受可卡因 (n=53) 的患者中有60.4%,在接受西洛梅塔佐林 (n=49) 的患者中有69.4%的患者发生了表性.
- 两组之间没有观察到出血率的统计学上显著差异 (p=0.41).
- 心率,血压和不良心脏事件在两组之间没有显著差异.
结论:
- 可卡因和西洛梅塔佐林在鼻内输管过程中预防表症方面表现出类似的有效性.
- 选择血管收缩剂时,应考虑除了疗效之外的因素,如成本和可用性.
- 选择血管收缩器的其他考虑因素包括价格,可用性和医疗法律方面.
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