与基线全身摄影相比,呈现为新病变的黑色细胞病变中恶性病变的预测因素:一个病例控制研究
S Chan1,2, P Guitera1,2,3, P Ferguson3,4
1Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
概括
在全身摄影 (TBP) 上的新型黑色素瘤的诊断可能具有挑战性. 识别特定的皮肤学预测因子对于在高风险人群中早期检测黑色素瘤至关重要.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 黑色素瘤的诊断依赖于识别新的或变化的病变.
- 全身摄影 (TBP) 有助于监测患有多种瘤的高风险患者.
- 解释TBP的动态变化需要谨慎,以防止不必要的切除.
研究的目的:
- 通过TBP确定新的黑色素细胞病变中恶性瘤的临床和皮肤镜指标.
- 提高高风险人群中呈现为新病变的黑色素瘤的诊断准确度.
主要方法:
- 从高风险队列中对黑色素瘤和黑色素细胞瘤的回顾性分析,呈现为TBP上的新病变.
- 黑色素瘤的组织病理学分类为"明确"和"边界"类型.
- 黑色素瘤和良性瘤之间的皮肤学特征的比较.
主要成果:
- 分析了60种黑色素瘤和110种瘤;黑色素瘤较大,发生在老年患者中.
- 黑色素瘤的关键皮肤学预测因素包括回归结构, hypo/amelanotic 颜色,不规则的色素,不对称的外围点/球体和不对称性.
- 特定的特征,如蓝白色的面,非典型的血管图案和闪亮的白色线条,仅在黑色素瘤中发现.
- 40%的黑色素瘤是边缘性,而18.3%的黑色素瘤在皮肤镜检查时没有特征.
结论:
- 黑色素瘤呈现为TBP上的新病变,可以在皮肤镜上缺乏特征,从而带来诊断挑战.
- 鉴定出皮肤学预测因子的存在需要在高风险患者中进行切除.
- 没有这些预测因子的病变需要密切监测,特别是在年轻患者中,所有侵入性黑色素瘤都显示了预测因子.
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