亚托皮性皮肤炎,多动症多动症和自闭症谱系障碍之间的共享症状:系统范围审查的协议
N Tan Nguyen1, Aviël Ragamin2, André B Rietman3
1Department of Dermatology, Erasmus MC, Rotterdam, Zuid-Holland, The Netherlands n.t.nguyen@erasmusmc.nl.
BMJ open
|June 26, 2024
概括
患有亚托皮肤炎 (AD) 的儿童患注意力缺陷/多动症障碍 (ADHD) 和自闭症谱系障碍 (ASD) 的风险更高. 本综述探讨了儿童这些疾病病理生理学的共同原因和知识差距.
科学领域:
- 儿科神经发育 儿童神经发育
- 皮肤病学 皮肤病学
- 遗传学和病理生理学
背景情况:
- 患有亚托皮性皮肤炎 (AD) 的儿童表现出神经发育障碍的患病率增加,包括注意力缺陷/多动症障碍 (ADHD) 和自闭症谱系障碍 (ASD).
- 在AD,ADHD和ASD儿童中观察到感官调节的共同挑战,但潜在的病因调查有限.
- 这些疾病的全球发病率不断上升,需要对它们的相互联系有更深入的了解.
研究的目的:
- 确定知识差距,并综合当前关于儿童群体中AD,ADHD和ASD共享病理生理学的假设.
- 审查和总结有关这些独特条件背后的共同生物机制的现有证据.
- 为了为未来的ADD,ADHD和ASD相关疾病的病因研究提供基础.
主要方法:
- 以乔安娜·布里格斯研究所手册为指导的范围审查方法.
- 在主要数据库中进行系统的文献搜索,包括Medline ALL,Embase,Web of Science和Cochrane控制试验中央注册表.
- 纳入标准侧重于研究儿童患有AD和ADHD和/或ASD症状的研究.
主要成果:
- 目前,关于共同病因因素的证据综合很少,突出显著的知识差距.
- 关于常见的病理生理路径的假设正在被整理.
- 该审查确定了需要进一步调查的具体领域,以阐明AD,ADHD和ASD之间的联系.
结论:
- 在了解儿童的亚托皮性皮肤炎,多动症多动症和ASD之间的共享病理生理学方面存在重大差距.
- 进一步的研究对于探索常见的病因因素和感官调节问题至关重要.
- 本次审查强调了需要综合研究方法来解决这些并发性疾病的需要.
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