关联BRAF或TERT促进器突变和先进的乳头甲状腺癌
Soji Toda1,2,3, Nao Saito2,4, Mei Kadoya3
1Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, Japan.
Anticancer research
|June 26, 2024
概括
TERT促进子突变与晚期乳头甲状腺癌有关,但BRAF突变没有. 在晚期病例中,TERT促进子突变没有影响整体存活率.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 乳头甲状腺癌 (PTC) 的预后受到BRAF和TERT促进体突变的影响.
- 先进的PTC病例往往呈现出不良预后,需要对遗传标记进行进一步调查.
研究的目的:
- 调查BRAF和TERT促进子突变与晚期乳头甲状腺癌的关联.
- 为了确定这些突变在晚期PTC病例中的预后影响.
主要方法:
- 追溯分析了51个晚期PTC病例 (A组) 和44个完全切除的病例 (C组).
- 使用基因组测试或桑格测序来检测BRAF和TERT促进体突变的基因分析.
- 在先进和非先进的PTC组之间比较突变流行率和生存结果.
主要成果:
- 在先进的PTC (A组) 中,TERT促进器突变的发生率明显高于非先进的病例 (C组) (70.6%与18.2%,p<0.001).
- 两组之间BRAF突变的患病率没有显著差异 (86.3%和90.9%).
- 在非高级PTC (C组) 中,TERT促进子突变与较短的无病存活期相关 (p<0.001),而BRAF突变没有显著影响.
结论:
- 与BRAF突变不同,TERT促进子突变与晚期乳头甲状腺癌有关.
- 在先进的PTC队列中,TERT促进体突变没有显著影响总体存活率.
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