相关实验视频

Updated: Jun 22, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

抑制STK39通过保护肠道屏障来削弱MASLD/MASH过程

Qing Xu¹, Fei Liu², Zhenru Wu¹

¹Institute of Clinical Pathology & Department of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, China.

Bioscience trends

|June 26, 2024

概括

抑制STK39可以保护肠道屏障,防止代谢功能障碍相关的脂肪肝炎 (MASH) 的进展. 这一发现为MASH提供了一个新的治疗策略,通过准肠道健康.

科学领域:

肝病学肝病学是一种肝病学.
胃肠病学胃肠病学
分子生物学分子生物学

背景情况:

STK39作为肠道屏障的负调节剂.
保护肠道屏障可能为代谢功能障碍相关的脂肪肝炎 (MASH) 提供治疗方法.

研究的目的:

研究STK39在MASH中的作用.
评估MASH中STK39抑制的治疗潜力.

主要方法:

从具有和没有代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的人类结肠组织中分析了STK39表达.
利用一种由高脂肪甲胺-胆缺乏饮食 (HFMCD) 诱导的MASH的小鼠模型.
给MASH小鼠服用STK39抑制剂 (ZT-1a) 或载体,并评估肝脏和肠道组织病理.

主要成果:

在MASLD患者的结肠组织中观察到升高的STK39水平.
在MASH小鼠中,STK39淘汰和ZT-1a治疗减少了肝炎和纤维化.
抑制STK39改善了肠道屏障功能,降低了炎症和透性,与减少肝损伤相关.

结论:

抑制STK39可以保护肠道上皮屏障.
准STK39是一种有前途的策略,通过保护肠道完整性来预防MASH的进展.

关键词:

肠道屏障肠道屏障肠道屏障这是MASLD/MASH.在STK39中,STK39是STK39.这就是ZT-1a.

更多相关视频

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Published on: January 7, 2022

相关概念视频

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...