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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Updated: Jun 17, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
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具有负原发性瘤边缘的不良组织学因素的接近边际与结肠癌的局部区域复发率增加无关.

Moustafa Moussally1, Maysoon M GamalEldin1, James E Lapinski2

  • 1Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.

American journal of surgery
|June 26, 2024
PubMed
概括

密切的特定结肠癌组织学因素的边缘,如血管内或内瘤,似乎不会增加局部区域复发风险. 这一发现表明,在结肠癌患者中,这些因素可能不需要额外的辅助治疗.

关键词:
大肠癌是什么意思 大肠癌是什么意思历史学因素 历史学因素地方地区复发情况.边缘 边缘 边缘 边缘

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科学领域:

  • 在瘤学瘤学.
  • 手术病理学手术病理学
  • 胃肠道癌症研究研究

背景情况:

  • 结肠癌切除中的阳性原发性瘤边缘与局部区域复发率的增加相关.
  • 有限的数据存在于与特定不良组织学因素的密切边缘 (<1毫米) 相关的局部区域复发风险.

研究的目的:

  • 调查不良组织学因素的近边缘 (<1毫米) 与结肠癌的局部区域复发之间的关联.
  • 为了测试假设,血管内瘤的近边缘,内瘤,瘤沉积物或外延伸不会提高局部区域的复发风险.

主要方法:

  • 从2007年至2020年对结肠癌 (腺癌) 手术切除的回顾性审查.
  • 纳入标准:阴性原发性瘤边缘与接近 (<1毫米) 的不良组织学因素 (血管内,内,瘤沉积物,外延伸) 接近介质或周边边缘.
  • 在包含的案例中分析复发模式.

主要成果:

  • 45例病例 (1%) 符合4435份病理学报告中的包括标准.
  • 内瘤是最常见的因素 (53%),其次是血管内瘤 (17.8%).
  • 9%的患者经历了复发,只有2人 (4%) 仅发生局部区域复发. 这些病例的不良因素是静脉内或静脉内和静脉内.

结论:

  • 该研究没有发现证据表明,血管内瘤,内瘤,瘤沉积物或外延伸的密切边缘与结肠癌局部区域复发风险增加有关.
  • 这些特定的近边缘组织学因素可能无法独立预测切除后的局部区域性复发.