3-O-酸胆酸:是代谢的破坏者还是协调者?
Runzhi Chen1, Xinhua Chen2, Jiangtao Gao1
1Key BioAI Synthetica Lab for Natural Product Drug Discovery, College of Bee and Biomedical Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China.
Trends in molecular medicine
|June 26, 2024
概括
肠道微生物修改胆汁酸,产生3-O-糖化胆汁酸和3-乙化胆汁酸. 这些化合物可能会影响代谢健康,为代谢功能障碍相关的脂肪肝炎和2型糖尿病提供新的治疗方法.
科学领域:
- 代谢学和肠道微生物组研究
- 内分泌学和代谢性疾病.
背景情况:
- 胆酸是参与代谢调节的关键信号分子.
- 肠道微生物群显著影响胆酸代谢和宿主健康.
- 胆酸代谢的失调与MASH和T2D等代谢障碍有关.
研究的目的:
- 研究特定的3-O-酸胆酸 (3-sucCA,3-acetyCA) 在代谢过程中的作用.
- 为了识别产生这些改性胆酸 (Bacteroides uniformis,Christensenella minuta) 的肠道微生物.
- 探索这些微生物 - 胆酸相互作用作为代谢疾病的治疗点的潜力.
主要方法:
- 与肠道微生物组成相关的胆酸概况的分析.
- 在体外或体外模型来评估3-sucCA和3-acetyCA的代谢作用.
- 鉴定参与胆汁酸酸化的微生物酶.
主要成果:
- 特定的肠道细菌Bacteroides uniformis和Christensenella minuta分别产生3-sucCA和3-acetyCA. 这两种细菌可以分别产生3-sucCA和3-acetyCA.
- 这些经过修改的胆汁酸表现出破坏或协调宿主代谢途径的能力.
- 有证据表明,微生物衍生的乙胆酸与代谢健康结果之间存在直接联系.
结论:
- 胆汁酸的微生物修饰是影响宿主新陈代谢的关键机制.
- 3-O-酸胆酸是MASH和T2D的潜在生物标志物和治疗点.
- 对肠道微生物群-胆酸轴的进一步研究可以为代谢性疾病管理开启新的策略.
相关概念视频
Overview of Fatty Acid Metabolism
30.4K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.4K
Hepatic Drug Excretion: Influencing Factors
123
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
123
Bile
745
Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
Bile is released when dietary fats enter...
Bile is released when dietary fats enter...
745
Lipid Absorption
430
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
430
Phase II Reactions: Acetylation Reactions
213
Acetylation, a phase II biotransformation reaction, introduces an acetyl group to drugs or their metabolites. Acetyltransferase enzymes facilitate this reaction, which resembles α-amino acid conjugation due to the addition of a functional group to the drug molecule.
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...
213
Liver Physiology
502
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
502


