在剂量反应研究后10年,志愿者对黄热病的接种后免疫持续时间 - 补充研究
Clarice Monteiro Vianna1, Tatiana Guimarães Noronha2, Luiz Antonio Bastos Camacho3
1Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos - FIOCRUZ, Rio de Janeiro, RJ, Brazil.
Vaccine
|June 26, 2024
概括
较低的黄热病 (YF) 疫苗剂量保持长期保护. 接种疫苗10年后,减少的黄疫苗剂量显示出与标准剂量相比的血清阳性和抗体标位,支持其有效性.
科学领域:
- 疫苗学 疫苗学 疫苗学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 标准黄热病 (YF) 疫苗被认为可以提供终身免疫力.
- 评估减少黄疫苗剂量的长期免疫性对于了解疫苗有效性和潜在的剂量节约策略至关重要.
研究的目的:
- 为了评估17DDYF疫苗10年后的不同减少剂量所产生的血清阳性和抗体标位.
- 为了与标准剂量相比较,降低了小疹疫苗剂量的长期免疫性.
主要方法:
- 一项剂量反应研究,涉及17DDYF疫苗,通过皮下注射剂量减少 (27.476 IU至31 IU).
- 在所有疫苗组中,在接种疫苗后10年评估了血清阳性和几何平均标位 (GMT).
主要成果:
- 接种疫苗10年后,所有降低剂量组的血清阳性率 (从83.1%到93%不等) 和GMT与标准剂量组保持相似.
- 在10年随访期间,在接受标准剂量和减少剂量的黄疫苗的组之间没有观察到血清阳性或抗体标位的显著差异.
结论:
- 减少17DD黄热病疫苗的剂量表明持续免疫性和血清阳性至少10年.
- 这些发现支持使用较低的幼年发疹疫苗剂量的潜力,有助于疫苗供应和可访问性.
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