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每天10和15μg的维生素D剂量之间的药理学差异

Tao You^1,2,3, Nadda Muhamad^1,2,4, Joseph Jenner¹

¹Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, L69 7BE, UK.

British journal of clinical pharmacology

|June 26, 2024

概括

通过比较维生素D摄入量,这项研究发现10和15微克/天都有效. 更高的15微克维生素D剂量有助于更多的人更快地达到最佳的25-基维生素D水平.

科学领域:

营养科学营养科学
药理动力学药理动力学
公共卫生公共卫生

背景情况:

英国和美国的维生素D摄入量建议有所不同:10微克/天 (英国) 和15微克/天 (美国).
了解血清25-基维生素D (25(OH) D) 度概况对于评估维生素D的疗效至关重要.

研究的目的:

为了比较10微克/天和15微克/天维生素D剂量之间的血清25...OH) D度概况.
根据这些不同摄入水平,预测英国成年人中的25...OH) D水平.

主要方法:

使用全球成人试验数据开发了一个基于生理学的药理动力学模型.
使用非线性混合效应建模分析维生素D和25(OH) D血清度.
该模型用于预测16岁及以上的英国成年人中的25...OH) D水平.

主要成果:

一个最小的生理学基础的药理动力学模型,根据体重进行调整,准确地预测了25...OH) D度.
模拟表明,95%的英国成年人每天服用10μg,在32周内将达到25±OH) D的50nmol/L.
服用15μg/天预测97.5%将在28周内达到50nmol/L.

结论:

10微克/天和15微克/天的维生素D剂量都对超过95%的英国人口有效.
15微克/天的剂量更有效,使97.5%的英国成年人能够达到50nmol/L血清25(OH) D.
更高的剂量还可以更快地达到25nmol/L的门,在4周内.

关键词:

基于生理学的药理动力学建模人口药理动力学人口药理动力学维生素D 维生素D是一种维生素.

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