患者特征对手术部位感染中的微生物组成的影响:来自国家监测研究的见解
Sarah Peisl1, Hugo Guillen-Ramirez1, Daniel Sánchez-Taltavull1
1Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.
The British journal of surgery
|June 26, 2024
概括
患者的年龄,体重指数 (BMI) 和手术持续时间显著影响导致手术部位感染 (SSI) 的细菌类型. 这些因素预测了微生物组成的变化,影响了感染的发展.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 医疗保健中的机器学习
背景情况:
- 手术部位感染 (SSIs) 是一个重大问题,已知由手术和患者因素的影响.
- 然而,这些因素对SSI微生物组成的具体影响尚未被彻底研究.
研究的目的:
- 确定与SSI的微生物组成相关的患者依赖预测因素.
- 探索年龄,BMI和手术持续时间等因素如何在各种手术过程中塑造SSI微生物学.
主要方法:
- 一项回顾性队列研究分析了瑞士国家感染监测计划中538,893名患者的数据.
- 机器学习模型,包括自适应增强和高斯天真贝叶斯,被用来从20个特征中识别预测因素.
- 分析的重点是那些有微生物伤口拭子的患者 (10,632名,18642名SSI中).
主要成果:
- 肠道细菌 (57%),葡萄球菌 spp. (31%) 和肠球菌种 (Enterococcus spp.) 的存在. (28%) 是最常见的SSI病原体.
- 年龄 (平均重要性0.260),BMI (0.224) 和手术持续时间 (0.221) 被确定为SSI微生物组成的强大,独立的预测因素.
- 增加年龄和手术持续时间,加上BMI下降,与从Staphylococcus spp.转移相关. 进入肠杆菌和肠球菌 spp.
结论:
- 患者的年龄,BMI和手术的持续时间是SSI微生物组成的关键预测因素,无论手术类型如何.
- 这些发现强调了患者特异性因素在SSI病变发生过程中的重要作用.
- 开发的机器学习模型的在线应用程序可用于外部验证.
相关概念视频
Factors Affecting the Risk of Infection
11.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.6K
Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
Sputum Studies II: Culture and Sensitivity
292
Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
292
Healthcare Associated Infections II: Preventive Measures
2.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.6K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.1K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.1K


