内分泌干扰和男性生殖系统障碍:没有答案的问题
1Centre for Reproductive Health, Institute for Regeneration & Repair, The University of Edinburgh, Edinburgh, UK.
Human reproduction (Oxford, England)
|June 26, 2024
概括
孕妇在怀孕期间接触内分泌干扰化学物质 (EDC) 和西方饮食可能会影响男性生殖健康,但影响可能源于胎儿生长受损而不是直接的荷尔蒙干扰.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 流行病学 流行病学
背景情况:
- 母亲暴露于内分泌干扰化学物质 (EDC) 与男性生殖健康问题有关,但证据不一致.
- 甲酸盐,如甲基甲酸盐 (DEHP),表现出模两可的效果,人类研究表明,在典型的暴露水平下,对胎儿雄激素生产没有影响.
研究的目的:
- 调查母体EDC暴露,饮食和男性生殖健康结果之间的复杂关系.
- 探索胎儿生长障碍 (FGI) 作为这些影响的潜在媒介的作用.
主要方法:
- 关于母亲暴露于EDC和男性生殖健康的流行病学证据的审查.
- 对甲酸盐对人类和老鼠胎儿丸的影响研究的分析.
- 检查西方饮食,EDC暴露和怀孕期间的FGI之间的相互作用.
主要成果:
- 关于EDC和男性生殖障碍的流行病学数据与饮食有关;西方饮食与更高的EDC暴露和更低的精子数量有关.
- 人类胎儿研究表明,高甲酸盐暴露对雄激素生产没有不良影响,与动物模型形成鲜明对比.
- 母亲的西方饮食,EDC暴露和工业接近与胎盘功能障碍和FGI有关,导致先天性男性生殖障碍.
结论:
- 孕产妇EDC与男性生殖系统疾病之间的联系可能是间接的,由FGI介导,而不是直接扰乱胎儿雄激素生产.
- 母亲的生活方式,包括饮食和环境暴露,显著影响胎儿发育和长期生殖健康.
- 需要进一步研究怀孕期间药物对胎儿生长和丸发育的影响.
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