评估医疗辅助生殖对自闭症谱系障碍风险影响
Omri Zamstein1, Tamar Wainstock2, Gil Gutvirtz3
1The Obstetrics and Gynecology Division, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel. omrizam9@gmail.com.
Journal of assisted reproduction and genetics
|June 26, 2024
概括
医疗辅助生殖,包括排卵诱导 (OI) 和体外受精 (IVF),不会增加儿童患自闭症谱系障碍 (ASD) 的风险. 这项大规模的人口研究发现,生育治疗和自闭症发展之间没有显著的联系.
科学领域:
- 生殖医学 生殖医学
- 发育儿科 发育儿科
- 流行病学 流行病学
背景情况:
- 由于不孕率的上升,医疗辅助生殖 (MAR) 技术越来越多地被使用.
- 马尔对胎儿发育和长期儿童健康的影响,特别是自闭症谱系障碍 (ASD) 风险,需要彻底调查.
研究的目的:
- 确定生育治疗,特别是排卵诱导 (OI) 和体外受精 (IVF),是否与后代患自闭症谱系障碍 (ASD) 的风险增加有关.
主要方法:
- 一项基于人口的队列研究分析了索罗卡大学医学中心的单独分娩.
- 自闭症谱系障碍 (ASD) 发病率在自然受孕的孩子和通过OI或IVF受孕的孩子之间进行了比较.
- 使用Kaplan-Meier生存曲线和Cox比例危险模型来分析累积发病率并调整混因素.
主要成果:
- 该研究包括115,081例怀孕;0.5%使用OI,1.7%使用试管婴儿.
- 与自然受孕 (0.6%) 相比,OI (2.1%) 和试管婴儿 (1.3%) 组的ASD初始发病率更高.
- 在对母亲的年龄,种族和性别进行调整后,OI和IVF都没有显示出与ASD风险的显著关联 (OI的aHR为0.83,IVF为1.34). 联合生育治疗也没有显著的关联 (aHR 1.11).
结论:
- 包括排卵诱导和体外受精在内的生育治疗与儿童患自闭症谱系障碍的风险增加没有显著关联.
- 这些发现为通过辅助生殖技术怀孕的儿童的神经发育结果提供了保证.
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