在风湿病学实践中通过临床药剂师合作解决与葡萄糖皮质激素有关的问题:一项前性后续研究
Melda Bahap-Kara1, Emine Sariyildiz2, Gozde K Yardimci2
1Department of Clinical Pharmacy, Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey. melda_610@hotmail.com.
Rheumatology and therapy
|June 26, 2024
概括
在类风湿性疾病中使用葡萄糖皮质类药物 (GC) 会导致频繁的问题,主要是由于监测不良而导致的不良药物事件. 临床药剂师有效解决了这些问题的80%,改善了患者的护理.
科学领域:
- 类风湿病学 类风湿病学
- 临床药房 临床药房
- 药物监督 药物监督 药物监督
背景情况:
- 葡萄糖皮质类药物 (GCs) 对于治疗风湿性疾病至关重要,但会带来诸如不良事件和复杂疗法等风险.
- 现有的关于GC相关问题的指导方针缺乏现实世界患者水平的数据.
- 这项研究通过识别和解决类风湿性疾病患者的GC相关问题来弥补这一差距.
研究的目的:
- 在患有类风湿性疾病的患者中识别与葡萄糖皮质激素 (GC) 相关的问题.
- 分析这些GC相关问题的原因和干预措施.
- 评估临床药剂师干预措施在解决GC相关问题的有效性.
主要方法:
- 在大学风湿病外科诊所进行的前性随访研究 (2021年1月至2022年6月).
- 临床药剂师在基线,3个月和6个月评估了156名患者的GC相关问题.
- 问题,原因和干预措施使用PCNE分类系统 (v9.1) 分类.
主要成果:
- 在66%的患者中发现了236个与GC相关的问题,94.1%是不良药物事件.
- 主要原因包括缺乏实验室监测 (41.5%) 和治疗不足 (39.8%).
- 临床药剂师提出了381项干预措施 (98%接受),解决了80.1%的问题.
结论:
- 与GC相关问题的高患病率需要在风湿性疾病患者中进行主动管理.
- 将临床药剂师整合到类风湿病团队中,可以提升早期识别和管理GC问题.
- 药剂师主导的干预措施显著改善了解决GC相关问题的方法.
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