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Updated: Jun 22, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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使用自主监督的深度学习计算基于质谱的无标签定量蛋白质组学数据的归算.

Henry Webel1,2, Lili Niu1, Annelaura Bach Nielsen1

  • 1Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.

Nature communications
|June 26, 2024
PubMed
概括

像PIMMS-VAE这样的深度学习归算方法通过恢复丢失的数据来增强质谱蛋白质组学分析. 这种方法在与酒精有关的肝病中发现了更重要的蛋白质,有助于预测疾病进展.

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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
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