投射到前 cingulate 的关节神经元限制在睡眠和行为期间的参与
Gal Atlan1, Noa Matosevich2,3, Noa Peretz-Rivlin1
1The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel.
Nature communications
|June 26, 2024
概括
投射到前带带皮质 (ACCp) 的关闭神经元调节睡眠和注意力期间的反应. 操纵ACCP活动会影响睡眠唤醒和注意力缺失,揭示了控制参与的共同功能.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 睡眠研究 睡眠研究
背景情况:
- 关闭层,一个皮质下大脑结构,已涉及到注意力和睡眠.
- 提出了一个潜在的共享功能来调节不同参与状态对刺激的反应.
研究的目的:
- 调查向前带皮质 (ACCp) 投射的闭膜神经元在调解注意力和睡眠中的作用.
- 测试假设ACCP神经元决定对刺激的反应能力,跨越参与轴.
主要方法:
- 在自然睡眠和注意力任务 (ENGAGE) 期间记录雄性小鼠的闭塞群动态.
- 利用化学遗传学来操纵ACCP神经元活动.
- 分析ACCP活动,感官反应,行为失误和任务执行策略 (探索与利用) 之间的相关性.
主要成果:
- 增加的ACCP活性与睡眠期间感官响应能力的降低相关.
- 在注意力任务中,较高的ACCP活动与脱离和行为失误有关,而较低的活动与过度参与和冲动错误相关.
- ACCp神经元的化学遗传激活减少了睡眠唤醒和任务期间的冲动错误.
- 勘探策略显示,与开采策略相比,ACCp与绩效的相关性更强.
结论:
- ACCp关节神经元在限制睡眠和目标导向行为期间的参与中发挥着关键作用.
- 这些发现突出了统一的神经机制,用于控制不同行为状态的响应性.
- 幽室对注意力和睡眠的影响,部分是由ACCP投影介导的.
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