在头癌中,CAFs和瘤细胞之间的交叉连接
Xinyang Li1, Celia González-Maroto1,2, Mahvash Tavassoli3
1Head and Neck Oncology Group, Centre for Host Microbiome Interaction, King's College London, Hodgkin Building, London, SE1 1UL, UK.
Cell death discovery
|June 26, 2024
概括
了解癌症相关纤维细胞 (CAF) 和它们在瘤微环境 (TME) 中的作用,是改善头支状细胞癌 (HNSCC) 治疗的关键. 结合CAF的新模型提供了更好的临床前测试平台.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 瘤微环境研究 研究
背景情况:
- 头部和部状细胞癌 (HNSCC) 是一种具有有限治疗成功的侵袭性恶性瘤.
- 对HNSCC的标准治疗通常会导致严重的副作用,在约50%的患者中缺乏有效性.
- 瘤微环境 (TME),特别是与癌症相关的纤维细胞 (CAF),显著影响HNSCC的进展和治疗耐药性.
研究的目的:
- 审查包括CAF在内的HNSCC瘤模型的开发和应用.
- 增强对TME中CAF和瘤细胞之间的复杂相互作用的理解.
- 为评估当前和新型HNSCC疗法提供最新的临床前测试平台.
主要方法:
- 对HNSCC瘤模型和CAF参与的现有文献的审查.
- 分析CAF如何调节瘤细胞的行为,包括细胞周期,干性和上皮-介质细胞过渡 (EMT).
- 讨论共培养和3D模型,以模拟HNSCC瘤环境,并实现治疗测试.
主要成果:
- CAFs是HNSCC TME的关键组成部分,由癌细胞分泌驱动.
- CAFs显著影响HNSCC的进展,茎状,EMT和对治疗的耐药性.
- 结合CAF的瘤模型对于研究TME动态和临床前药物评估至关重要.
结论:
- 了解CAF与瘤细胞的相互作用对于克服HNSCC治疗耐药性至关重要.
- 具有CAF的高级HNSCC模型是有效的临床前测试所必需的.
- 针对CAF-TME相互作用有望开发更有效的HNSCC疗法.
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