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Updated: Jun 22, 2025

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

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髓反应性B细胞以依赖IL-23的方式加剧CD4+ T细胞驱动的中枢神经系统自身免疫

Mohamed Reda Fazazi1, Prenitha Mercy Ignatius Arokia Doss1, Resel Pereira2

  • 1axe Neurosciences, Centre de recherche du Centre hospitalier universitaire (CHU) de Québec - Université Laval, Pavillon CHUL, 2705 boul Laurier, Quebec City, G1V 4G2, QC, Canada.

Nature communications
|June 26, 2024
PubMed
概括

髓寡细胞糖蛋白 (MOG) 特定的B细胞通过产生IL-23驱动多发性硬化症 (MS) 病原体,导致T助手17 (Th17) 细胞积累和疾病恶化. 阻断IL-23可降低炎症和外围T辅助细胞 (Tph) 活动.

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