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Updated: Jun 22, 2025

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催化 [4+2]-和 [4+4]-循环添加,使用与 furan 融合的环butanone 作为特权的 C4 合成子

Kemiao Hong1, Mengting Liu2, Lixin Qian2

  • 1School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China.

Nature communications
|June 26, 2024
PubMed
概括

研究人员开发了一种新的原子经济循环添加方法,使用 furan-fused cyclobutanones (FCBs) 作为 C4 合成子. 这种多功能策略可以合成具有潜在抗癌活性的有价值的化乳酸盐.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.
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