[不同内镜评分方法在儿童克罗恩病中评估疾病活性时的价值]
Wen Deng1, Zhong-Yue Li1, Bo Liu1
1Department of Gastroenterology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/Ministry of Education Key Laboratory of Child Development and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chonging Key Laboratory of Pediatrics, Chongqing 400014, China.
像CDEIS和SES-CD这样的内镜评分方法可以评估儿科克罗恩病 (CD) 活动,但与儿科克罗恩病活动指数 (PCDAI) 不完全一致. 升高的ESR和CRP水平有效预测了CD儿童的疾病活性.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠道疾病研究研究
- 诊断准确性研究 诊断准确性研究
背景情况:
- 儿科克罗恩病 (CD) 需要对疾病活动进行准确的评估,以有效管理.
- 存在各种内镜评分系统,但它们与儿科CD的临床指数的一致性尚未完全确立.
研究的目的:
- 评估不同内镜评分方法在儿童克罗恩病 (CD) 中评估疾病活性时的实用性.
- 为了将内镜分数与儿科克罗恩病活动指数 (PCDAI) 和实验室标记器进行比较.
主要方法:
- 70名儿科CD患者使用PCDAI和多种内镜评分系统 (CDEIS,SES-CD,易斯评分,CE-CD) 进行评估.
- 斯皮尔曼等级相关性和卡帕测试分析了分数之间的关系和一致性.
- ROC曲线分析评估了实验室指标 (ESR,CRP,HCT,ALB) 在预测内学活性方面的诊断有效性.
主要成果:
- 在PCDAI和CDEIS (r=0.696),SES-CD (r=0.680),易斯评分 (r=0.540) 和CE-CD (r=0.502) 之间观察到中等的正相关性.
- 内镜评分和PCDAI之间的一致性很差 (Kappa=0.069-0.226).
- 与PCDAI和结肠镜得分相比,ESR和CRP的相关性中等,与HCT和ALB相比,疾病活性的预测值更高.
结论:
- 内镜评分系统 (CDEIS,SES-CD,易斯评分,CE-CD) 对于评估儿科CD活动是有价值的,但与PCDAI的一致性有限.
- 红细胞沉积率 (ESR) 和C反应蛋白 (CRP) 的升高有效预测儿科CD的临床和内镜疾病活动.
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