[在双胞胎早产婴儿中发生支气管肺功能障碍的危险因素:多中心研究]
Yu-Wei Fan1, Yi-Jia Zhang, He-Mei Wen
1Department of Pediatrics, Third Affiliated Hospital of Guangzhou Medical University/Guangdong Provincial Key Laboratory of Major Obstetric Diseases/Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology/Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangzhou 510150, China.
概括
出生体重不一致和较小的妊娠年龄分娩是早产双胞胎中支气管肺功能障碍症 (BPD) 的关键危险因素. 较高的妊娠年龄可以保护这些脆弱的婴儿免受BPD的发展.
科学领域:
- 新生儿科学 新生儿科学
- 周围生理学 周围生理学
- 儿科肺病学 儿科肺病学
背景情况:
- 支气管肺功能障碍症 (BPD) 是早产婴儿的一个重大并发症.
- 双胞胎怀孕在管理早产婴儿方面存在独特的挑战.
- 确定双胞胎中BPD的特定风险因素对于有针对性的干预至关重要.
研究的目的:
- 在早产双胞胎 (<34周妊娠年龄) 中识别BPD的风险因素.
- 在临床实践中为双胞胎早产婴儿早期BPD识别奠定基础.
- 分析双胞胎对内BPD的产后风险因素.
主要方法:
- 对904对妊娠年龄<34周 (2018-2020) 的双胞胎双胞胎进行了回顾性分析.
- 婴儿被分为三组:双胞胎患有BPD,一个双胞胎患有BPD,没有双胞胎患有BPD.
- 多变量和条件后勤回归分析以确定风险和保护因素.
主要成果:
- 出生体重异常>25%是BPD的独立风险因素 (OR=3.370).
- 出生时更高的妊娠年龄是预防BPD的保护因素.
- 怀孕年龄较小的出生是双胞胎个体BPD的独立风险因素 (OR=5.017).
结论:
- 妊娠年龄,双胞胎之间出生体重不一致以及SGA出生与早产双胞胎的BPD发展有关.
- 这些因素可以帮助在这个高风险人群中早期识别和管理BPD.
- 进一步研究针对这些风险因素的具体干预措施是有必要的.
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