在马匹中对-4,9-二烯-3,17-的兴奋剂控制
Helen S M Ho1, Adrian F Farrington2, Amanda J Bond3
1Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Drug testing and analysis
|June 26, 2024
概括
埃斯特拉-4,9-二烯-3,17-二烯 (dienedione) 是一种被证实在雄性马中具有内源性的类固醇-类固醇 (AAS). 它的代谢物M3a和M3b是检测二二在鱼中滥用的关键.
科学领域:
- 兽医药理学 兽医药理学
- 内分泌学 在内分泌学.
- 运动反兴奋剂 运动反兴奋剂
背景情况:
- 雌激素-4,9-二烯-3,17-二烯 (dienedione),一种类固醇-类固醇 (AAS),作为健美补充剂销售.
- 在人类和马类运动中禁止使用迪内迪,因为它具有提高表现的潜力.
- 虽然最初由于其罕见的4,9-二烯配置被认为是合成的,但最近证实了整个雄性马中的二二二烯的内源性质.
研究的目的:
- 为了研究二二的消除和生物转化在割马 (geldings).
- 确定关键代谢物,以有效控制马体育中的二二滥用.
主要方法:
- 在连续七天内,每天给三只子服用单次口服1500毫克的二二粉剂量.
- 尿液和血样本的分析,以识别和量化二二代谢物.
- 通过基化和还原途径形成的体内代谢物的定理.
主要成果:
- 鉴定了几种体内代谢物,包括氧化二二二 (M2a-M5) 和氧化M1 (M6a-M8b).
- 来自二二的代谢物M3a和M3b显示了最长的检测时间.
- 丁二没有在鱼中检测到,但其代谢物在尿液中可检测长达2-5天,在血中可检测长达0.4-4天.
结论:
- 这项研究阐明了二在鱼中的代谢命运,这对于了解其消除至关重要.
- 代谢物M3a和M3b是检测在鱼中使用二二的有价值的标.
- 基于这些特定代谢物的长时间检测窗口,可以制定有效的反兴奋剂策略.
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