血管埃勒斯-丹洛斯综合征和怀孕:一个系统性审查
Théo Haem1, Betty Benson2, Amandine Dernoncourt3,4
1Department of Gynaecology and Obstetrics, Centre Hospitalier Universitaire Amiens Picardie, Amiens, France.
患有血管埃勒斯-丹洛斯综合征 (vEDS) 的女性怀孕存在重大风险,包括高流产率,早产和孕产妇死亡率. 建议在37周进行预定的剖腹产,以减轻并发症.
科学领域:
- 产科和妇科 产科和妇科
- 遗传学 是一个遗传学.
- 血管医学 血管医学
背景情况:
- 血管埃勒斯-丹洛斯综合征 (vEDS) 是一种遗传性疾病,增加了血管,子宫和消化系统并发症的风险.
- 由于这些固有的风险,vEDS患者的怀孕管理存在独特的挑战.
研究的目的:
- 系统地审查现有的关于被诊断为vEDS的妇女怀孕并发症的文献.
- 确定与vEDS怀孕相关的关键风险和结果.
主要方法:
- 在PubMed和Embase数据库的系统文献搜索中,使用与vEDS和怀孕相关的术语.
- 纳入标准侧重于报告患有vEDS的妇女产科结果的研究.
- 数据提取和分析已识别的出版物.
主要成果:
- 包括6项包括412个怀孕的研究.
- 观察到的高率:13.8%的流产,8.8%的早产,11.3%的产科关节损伤.
- 显著的孕产妇死亡率为每次怀孕5.7%.
结论:
- 患有vEDS的女性面临子宫破裂,血管和消化系统事件以及怀孕期间死亡的风险增加.
- 建议在妊娠37周进行剖腹产,以最大限度地降低产周风险,并避免驱逐的努力.
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