疟疾的总抗氧化剂状态水平:系统性审查和元分析
Kwuntida Uthaisar Kotepui1, Aongart Mahittikorn2, Wanida Mala1
1Medical Technology, Faculty of Science, Nakhon Phanom University, Nakhon Phanom, 48000, Thailand.
Malaria journal
|June 26, 2024
概括
疟疾显著降低了总抗氧化剂状态 (TAS),表明氧化应激增加. 较低的TAS水平与严重的疟疾和较高的寄生虫密度相关,这表明TAS是潜在的疾病严重性生物标志物.
科学领域:
- 生物化学 生物化学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 疟疾是全球主要的健康问题.
- 这种疾病与显著的氧化压力有关.
- 总抗氧化剂状态 (TAS) 水平在疟疾患者中受到显著影响.
研究的目的:
- 系统地审查和元分析疟疾患者和健康个体之间的TAS水平差异.
- 调查TAS水平,疾病严重程度和疟疾中的寄生虫密度之间的相关性.
主要方法:
- 在多个数据库 (Embase,MEDLINE,PubMed,Scopus等) 中进行了全面的文献搜索. ) 的情况.
- 从20项选定的研究中获得的数据在质量和数量上进行了分析.
- 使用随机效应模型将TAS水平差异组合起来,Hedges的g作为效应大小.
主要成果:
- 与对照组相比,在疟疾患者中观察到TAS水平的显著下降 (P < 0.01).
- 亚组分析表明,TAS变异受地区,年龄,Plasmodium物种和测量方法的影响.
- 在严重的疟疾病例和具有高寄生虫密度的病例中发现了较低的TAS水平.
结论:
- 总抗氧化剂状态 (TAS) 可能成为疟疾风险和严重程度的有价值生物标志物.
- 这些发现表明,TAS减少,氧化应激增加和疟疾进展之间存在强烈联系.
- 建议进行进一步的研究以验证这些发现并探索潜在的机制.
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