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Updated: Aug 8, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: October 26, 2015

氨基酸替代物,以补偿酶中的大型聚酸缺失

C Ho, M Jasin, P Schimmel

    Science (New York, N.Y.)
    |July 26, 1985
    PubMed
    概括

    酶工程可以通过使用特定的突变恢复因大删除而丢失的活性. 这些蛋白质设计策略显著增强了催化功能,甚至补偿了缺失的序列.

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