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[LINC00475在多发性骨髓瘤中的表达和临床意义]

Ling Lu¹, Dan Guo¹, Le-Min Hong¹

¹Department of Hematology, The Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.

Zhongguo shi yan xue ye xue za zhi

|June 27, 2024

概括

多发性骨髓瘤 (MM) 患者的血清LINC00475显著升高,有助于诊断. 它的表达与关键预后指标相关,如β-2微型血球蛋白和ISS阶段.

科学领域:

生物化学生物化学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

多发性骨髓瘤 (MM) 是一种血液性恶性瘤,其特征是血细胞的不受控制的增殖.
准确的诊断和预后生物标志物对于有效的MM管理至关重要.

研究的目的:

为了研究MM患者血清中长非编码RNALINC00475的表达水平.
评估血清LINC00475在MM中的临床意义和诊断价值.

主要方法:

来自108名MM患者和5个MM细胞系的血清样本使用实时光定量PCR分析了LINC00475表达.
采用接收器操作特征 (ROC) 曲线分析来评估LINC00475.5的诊断准确性.
在LINC00475水平和患者临床特征之间进行了相关性分析.

主要成果:

与对照组相比,LINC00475表达在MM患者和细胞系的血清中显著上调 (P < 0.05).
ROC分析表明,MM中的LINC00475具有良好的诊断价值,曲线下的面积 (AUC) 为0.924,灵敏度为83.3%,特异性为91.7%.
在MM患者中,升高的LINC00475水平与较高的β-2微型血球蛋白和cystatin C,较低的白蛋白和高级国际分期系统 (ISS) 阶段 (II和III) 相关 (P <0.05).

结论:

血清LINC00475作为一个有价值的生物标志物,用于区分MM患者和健康个体.
在多发性骨髓瘤中,LINC00475的表达与已确定的预后指标有显著的相关性,包括β-2微型血球蛋白,白蛋白和ISS阶段.

关键词:

多发性髓瘤;多发性髓瘤;

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