相关实验视频

Updated: Jun 22, 2025

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
07:56

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time

Published on: May 30, 2021

3.2K

多态α-同核素二次体的初级核化取决于铜度和确定的铜结合点

Carmia Blacher1,2,3, Karina Abramov-Harpaz1,2,3, Yifat Miller1,2,3

  • 1Department of Chemistry, Ben-Gurion University of the Negev, Beér-Sheva 8410501, Israel.

Biomolecules
|June 27, 2024
PubMed
概括

铜在帕金森病中影响α-synuclein (AS) 核化. 这项研究揭示了不同的铜度和结合点在原子分辨率下调节AS寡合体形成,提供了新的治疗策略.

关键词:
帕金森病是帕金森氏症的一种疾病.粉样蛋白是什么 粉样蛋白金属离子金属离子神经退行性疾病的神经退行性疾病寡合物是指一些寡合物.多形态主义的多态主义.蛋白质聚合蛋白质的聚合物自动组装的自动组装机α-synuclein 是一种同核蛋白.

更多相关视频

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

9.6K
Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions08:40

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions

Published on: June 23, 2022

2.9K

相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.5K